Онкология SURGICAL TREATMENT OF NON-SMALL CELL LUNG CANCER PATIENTS WITH BRAIN METASTASIS: RESULTS AND PROGNOSIS
eng
ONCOLOGY BULLETIN OF THE VOLGA REGION

Scientific-practical Journal for general practitioners and researchers

Search

SURGICAL TREATMENT OF NON-SMALL CELL LUNG CANCER PATIENTS WITH BRAIN METASTASIS: RESULTS AND PROGNOSIS

O.V. Pikin1, A.Kh. Trakhtenberg1, A.S. Kartoveshchenko1, A.A. Potapov2, A.M. Zaytsev1,
V.A. Glushko1, K.I. Kolbanov1, D.A. Vursol1, M.I. Kurzhupov1

1 P. A. Herzen Moscow Cancer Research Institute
2 N. N. Burdenko Research Institute of Neurosurgery, RAMS, Moscow, Russia

 

Abstract. Purpose: to study the effectiveness of surgical treatment in NSCLC patients with brain metastasis, and to determine indications for the method and main prognostic factors. Materials and methods: Treatment experience of 82 patients with resectable NSCLC and brain metastasis is presented. Average age was 59,6 years. Male patients were prevalent — 82,9% (68 patients). Adenocarcinoma was verified in 58 patients (70,7%). Histological structure of tumor in the lung was similar to one of the metastatic lesion in the brain in all cases. In 61 patient brain metastasis were diagnosed metachronously to primary lung tumor, in 21 patients — synchronously. Brain metastasis diagnosed more than 6 month after surgery on lungs were determined as metachronic. All the patients in the group with synchronous metastasis, except for one, who’s brain surgery was performed simultaneously, the first step was performed by brain metastasis removal, 4—6 weeks later pulmonary surgery was performed.

Results: Overall 1, 3- and 5-year survival after removal of brain metastasis criterea was 52%, 29% and 25,6% respectively. Median survival — 38 month. The main prognostic factors include status ofintrathoracic lymph nodes, synchronous and metachronous brain metastasis.

Conclusion: Removing primary lung tumor and resectable brain metastasis in patients with NSCLC improves long-term outcomes.

Key words: lung cancer, brain metastasis, surgical treatment.

 





Наши партнеры



Copyright © 2014 | Все права защищены
RAFANDOS.COM | SUPPORT