Онкология METHOD OF COMBINED RADIOMODIFICATION IN COMPLEX TREATMENT OF LOCALLY ADVANCED CERVIСАL CANCER
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METHOD OF COMBINED RADIOMODIFICATION IN COMPLEX TREATMENT OF LOCALLY ADVANCED CERVIСАL CANCER

A.V. Panov1,2, M.V. Burmistrov2, S.V. Zinchenko2, I.S. Raginov3, E.Yu. Mindubaev1, P.M. Manenkov3

1 Tatarstan Cancer Center, Kazan

2 Kazan State Medical Academy, Kazan

3 Kazan State Medical University, Kazan

 

 

Panov A.V. — PhD, Head of the Gynecology Department № 1, Assistant Professor of Obstetrics and Gynecology Department № 2
29 Sibirskiy Trakt, Kazan, Russian Federation, 420029, tel. (843) 519-26-50, e-mail: Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра., Этот адрес электронной почты защищён от спам-ботов. У вас должен быть включен JavaScript для просмотра.

 

 

Abstrsct. Presents the results of complex treatment of 63 patients with squamous cell cervical cancer stage IIb. All patients in the preoperative period used a combination of combined radiation therapy (external + internal) and intravenous administration of cisplatin with the subsequent operation of Wertheim. At the stage of preoperative chemoradiation therapy 36 of 63 patients were performed rectal insufflation of radiomodificator: ozone-oxygen mixture. In the postoperative period the comparative analysis of therapeutic pathomorphosis of the tumor. The proposed scheme preoperative chemoradiation therapy of cervical cancer in conditions of radiomodification ozone-oxygen mixture led to the achievement of therapeutic pathomorphosis of IV degree from 47.2% of patients, which is confirmed by morphometric assessment of the effectiveness of the damaging effect, and also allowed the increase of one- and three-year survival rate of patients to 92.3 and 70.8% respectively.

Key words: squamous cell cervical cancer, chemoradiotherapy, radiomodification, ozone, therapeutic pathomorphosis, morphometric analysis.

 

 





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