Онкология EVALUATION OF THE SENSITIVITY OF HE4 SERUM TUMOR MARKER FOR DIAGNOSTICS OF OVARIAN CANCER
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ONCOLOGY BULLETIN OF THE VOLGA REGION

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EVALUATION OF THE SENSITIVITY OF HE4 SERUM TUMOR MARKER FOR DIAGNOSTICS OF OVARIAN CANCER

R.Sh. Khasanov1,2,3, M.S. Katsyuba1,2, G.A. Usmanova2, G.Z. Muratova4, A.F. Akhmetzyanova2, A.V. Panov1,2, E.Yu. Ratner1

1 Kazan State Medical Academy
2 Tatarstan Cancer Center, Kazan
3 Volga Region branch of RCRC named after N.N. Blokhin of the RAMS, Kazan
4 Kazan (Volga Region) Federal University, Kazan

 

Hasanov R.Sh. — D. Med. Sc., Professor, Head of the Department of Oncology and Surgery KSMA, chief physician of Tatarstan Cancer Center, Director of the Volga branch of RCRC named after N.N. Blokhina of the RAMS 29 Sibirskiy trakt St., Kazan, Russian Federation, 420029, tel. (843) 519-26-00

 

Abstract. The aim of the study was to investigate the sensitivity of the concentrationof HE4 tumor marker in patients with ovarian cancer at the time of diagnosis. We subjected to a retrospective analysis all cases of ovarian cancer (N=109), taken on record in the Republic of Tatarstan from 1 January to 31 December 2012, in which have been defined concentration of HE4 tumor marker before beginning cancer treatment with method HE4 EIA.
The median concentration of HE4 was 492,7 (± 30,4) pmol/l, the minimum — 33.7 pmol/l, maximum — 904 pmol/l. Given the discriminatory level 150 pmol/l in the kit instructions HE4 EIA (CanAg, Fujirebio Diagnostics) HE4 sensitivity for the diagnosis of ovarian cancer (after excluding the borderline tumors) was 71.8% (95% CI: 66.4-77, 3%), and for the combined group, including both invasive cancer and borderline tumors 68.8% (95% CI: 62.9-74.7%). However, for stage I-II sensitivity was significantly lower — 44.7% for invasive cancer and 35.3% for the combined group including borderline tumors. The sensitivity of the combination of two of the studied markers was 93.6%.
Key words: HE4 serum tumor marker, ovarian cancer.

 





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