Онкология RESULTS OF BEAM THERAPY AT HIGH-GRADE GLIOMAS OF DEPENDING ON PROGNOSTIC FACTORS
eng
ONCOLOGY BULLETIN OF THE VOLGA REGION

Scientific-practical Journal for general practitioners and researchers

Search

RESULTS OF BEAM THERAPY AT HIGH-GRADE GLIOMAS OF DEPENDING ON PROGNOSTIC FACTORS

T.R. Izmailov, G.A. Panshin, P.V. Datsenko

FSE «Russian Scientific Center of Roentgenoradiology» of the Ministry of Health of the Russian Federation, Moscow

 

Abstract. In the USA and Europe standards of complex treatment of malignant intracerebral gliomas is the comprehensive approach, namely at the first stage surgical removal of a tumor, then a radiotheraphy course against reception of chemotherapy and after course chemotherapy is carried out. The current standard of beam therapy at primary patients with high-grade gliomas the traditional mode of care remains 60 Gy in 30 fractions on a bed of a remote (residual) tumor is at 4, and 54 Gy in 27 fractions — for patients with gliomas 3.

The main criteria in development of the program of special treatment remain the histologic conclusion, a functional condition (index Karnovsky) and age of the patient, that is major factors on which the RPA model, and as modified adapted model RSCRR developed in the Center is based.

It should be noted that use of a traditional mode of a fractionation is the most preferable in to group patients of the I—IV classes of model RSCRR, and in the V class use of a mode of an average fractionation of 3 Gy is possible.

It is expedient to patients of the V class of model RSCRR to carry out beam therapy after surgical removal of a tumor within 4—6 weeks. Considerably brought level of total doses is important on all the classes I—V, developed model RSCRR. Radiotherapy with chemotherapy treatment and use of the fixing device in group of patients of the V class of model don't improve an indicator of the general survival rate. The volume surgical removal of an intracerebral glial tumor directly influences the general survival rate, thus dependence is traced in all prognostic classes of model RSCRR. Key words: brain tumors, radiation therapy, adapted model RSCRR.





Наши партнеры



Copyright © 2014 | Все права защищены
RAFANDOS.COM | SUPPORT